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Submitted: 03 Jan 2025
Revision: 11 May 2025
Accepted: 28 Jun 2025
ePublished: 30 Jun 2025
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J Educ Community Health. 2025;12(2): 122-131.
doi: 10.34172/jech.3356
  Abstract View: 36
  PDF Download: 12

Physical Activity

Review Article

Effects of Different Sedentary Interruption Interventions on Vascular Function in Adults: A Network Meta-Analysis

Tongyan Zhang 1 ORCID logo, Anastasiia V. Kabachkova 1,2* ORCID logo, Xianbo Qu 1 ORCID logo

1 Faculty of Physical Education, Tomsk State University, Tomsk 634050, Russia
2 Institute of Integrative Healthcare, Siberian State Medical University, Tomsk 634050, Russia
*Corresponding Author: Anastasiia V. Kabachkova, Email: avkabachkova@gmail.com

Abstract

Background: Interrupting sedentary behavior through intermittent activity may prevent or ameliorate vascular dysfunction. This study aimed to compare and rank the effectiveness of different sedentary interruption interventions on vascular function in adults using a network meta-analysis (NMA).

Methods: A systematic search was conducted in PubMed, Cochrane, Embase, and Web of Science databases to identify the randomized controlled trials that investigated the impact of sedentary interruption interventions on adult vascular function. The retrieval period was from inception to October 2024. Paired analyses and NMAs were conducted using the random-effects model.

Results: This research included 27 studies, which involved five sedentary intervention methods and covered a total of 483 participants. Sedentary interruption interventions can effectively improve the levels of blood flow (mean difference [MD] = 0.33, 95% confidence interval [CI]: 0.18, 0.48), mean arterial shear rate (MD = 0.32, 95% CI: 0.15 0.49), flow-mediated dilation (FMD)% (MD = 0.43, 95% CI: 0.26, 0.59), and carotid-to-ankle pulse-wave velocity (PWV; MD = -1.12, 95% CI: -1.50, -0.73). The surface under the cumulative ranking curve revealed that aerobic activities were the most effective interventions in improving mean arterial pressure, blood flow, and mean arterial shear rate. Lower-extremity activities could most effectively improve FMD%, carotid-to-ankle PWV, and carotid-to-femoral PWV, and standing achieved good results in improving carotid-to-radial PWV.

Conclusion: Interventions to interrupt sedentary behavior effectively enhance vascular health in sedentary populations. Aerobic activities and lower-extremity activities have demonstrated relatively strong advantages in improving vascular function.



Please cite this article as follows: Zhang T, Kabachkova AV, Qu X. Effects of different sedentary interruption interventions on vascular function in adults: a network meta-analysis. J Educ Community Health. 2025; 12(2):122-131. doi:10.34172/jech.3356
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